| 2022-04-02 13:00:23April 2, 2022 |   West Seneca East vs Penfield Varsity | 2 - 15 | West Seneca East High School |
| 2022-04-05 19:00:03April 5, 2022 |  Webster Thomas vs Penfield Varsity | 13 - 12 | Webster Thomas High School |
| 2022-04-07 17:00:12April 7, 2022 |  Penfield Varsity vs Brighton | 7 - 6 | Penfield High School |
| 2022-04-09 13:00:13April 9, 2022 |  West Genesee vs Penfield Varsity | 8 - 7 | West Genesee High School |
| 2022-04-12 18:15:26April 12, 2022 |  Spencerport vs Penfield Varsity | 9 - 10 | Spencerport High School |
| 2022-04-14 19:00:16April 14, 2022 |  Penfield Varsity vs Greece Storm | 15 - 2 | Penfield High School |
| 2022-04-21 13:00:30April 21, 2022 |  Comsewogue vs Penfield Varsity | 8 - 6 | Comsewogue High School |
| 2022-04-26 19:00:32April 26, 2022 |  Pittsford vs Penfield Varsity | 5 - 4 | Pittsford Sutherland High School |
| 2022-04-28 17:00:33April 28, 2022 |  Penfield Varsity vs Fairport | 4 - 6 | Penfield High School |
| 2022-04-30 11:00:29April 30, 2022 |  Penfield Varsity vs Orchard Park | 16 - 4 | Penfield High School |
| 2022-05-03 17:00:17May 3, 2022 |  Rush Henrietta vs Penfield Varsity | 8 - 13 | Rush-Henrietta High School |
| 2022-05-05 19:00:58May 5, 2022 |  Penfield Varsity vs Hilton | 10 - 9 | Penfield High School |
| 2022-05-07 19:00:43May 7, 2022 |  Victor vs Penfield Varsity | 14 - 4 | Victor High School |
| 2022-05-13 19:00:31May 13, 2022 |  Canandaigua vs Penfield Varsity | 12 - 6 | Canandaigua Academy |
| 2022-05-17 19:00:17May 17, 2022 |  Webster Schroeder vs Penfield Varsity | 5 - 8 | Webster Schroeder High School |
| 2022-05-19 19:00:56May 19, 2022 |  Irondequoit vs Penfield Varsity | 3 - 9 | Irondequoit High School |
