| 2021-05-01 18:00:22May 1, 2021 |   Penfield Varsity vs West Genesee | 9 - 8 | Penfield High School |
| 2021-05-05 19:30:02May 5, 2021 |  Gates Chili vs Penfield Varsity | 3 - 17 | Gates Chili High School |
| 2021-05-07 17:45:56May 7, 2021 |  Churchville Chili vs Penfield Varsity | 5 - 15 | Fairbanks Road Elementary School |
| 2021-05-10 19:00:08May 10, 2021 |  Pittsford vs Penfield Varsity | 11 - 12 | Pittsford Sutherland High School |
| 2021-05-12 19:30:21May 12, 2021 |  Penfield Varsity vs Canandaigua | 3 - 9 | Penfield High School |
| 2021-05-14 19:30:01May 14, 2021 |  Penfield Varsity vs Fairport | 9 - 8 | Penfield High School |
| 2021-05-17 19:30:45May 17, 2021 |  Hilton vs Penfield Varsity | 7 - 12 | Hilton High School |
| 2021-05-19 19:30:25May 19, 2021 |  Penfield Varsity vs Webster Thomas | 3 - 8 | Penfield High School |
| 2021-05-21 19:30:03May 21, 2021 |  Penfield Varsity vs Victor | 3 - 9 | Penfield High School |
| 2021-05-24 17:30:06May 24, 2021 |  Rush Henrietta vs Penfield Varsity | 5 - 14 | Rush-Henrietta High School |
| 2021-05-26 19:00:50May 26, 2021 |  Brighton vs Penfield Varsity | 3 - 16 | Brighton High School |
| 2021-05-28 19:30:02May 28, 2021 |  Penfield Varsity vs Spencerport | 12 - 8 | Penfield High School |
| 2021-05-31 11:30:57May 31, 2021 |  Irondequoit vs Penfield Varsity | 8 - 11 | Irondequoit High School |
| 2021-06-02 19:30:39June 2, 2021 |  Penfield Varsity vs Webster Schroeder | 13 - 6 | Penfield High School |
