| 2021-05-01 18:00:22May 1, 2021 |   Penfield Varsity vs West Genesee | 18:00:226:00 pm | Penfield High School |
| 2021-05-05 19:30:02May 5, 2021 |  Gates Chili vs Penfield Varsity | 19:30:027:30 pm | Gates Chili High School |
| 2021-05-10 19:00:08May 10, 2021 |  Pittsford vs Penfield Varsity | 19:00:087:00 pm | Pittsford Sutherland High School |
| 2021-05-12 19:30:21May 12, 2021 |  Penfield Varsity vs Canandaigua | 19:30:217:30 pm | Penfield High School |
| 2021-05-14 19:30:01May 14, 2021 |  Penfield Varsity vs Fairport | 19:30:017:30 pm | Penfield High School |
| 2021-05-17 19:00:45May 17, 2021 |  Hilton vs Penfield Varsity | 19:00:457:00 pm | Hilton High School |
| 2021-05-19 19:30:25May 19, 2021 |  Penfield Varsity vs Webster Thomas | 19:30:257:30 pm | Penfield High School |
| 2021-05-21 19:30:03May 21, 2021 |  Penfield Varsity vs Victor | 19:30:037:30 pm | Penfield High School |
| 2021-05-26 19:00:50May 26, 2021 |  Brighton vs Penfield Varsity | 19:00:507:00 pm | Brighton High School |
| 2021-05-28 19:30:02May 28, 2021 |  Penfield Varsity vs Spencerport | 19:30:027:30 pm | Penfield High School |
| 2021-05-31 19:00:57May 31, 2021 |  Irondequoit vs Penfield Varsity | 19:00:577:00 pm | Irondequoit High School |
| 2021-06-02 19:30:39June 2, 2021 |  Penfield Varsity vs Webster Schroeder | 19:30:397:30 pm | Penfield High School |
